Effect of Micro- and Nanoparticles of Ampicillin Trihydrate on Blood Medium: A Voltammetric Study

Muhammed Mizher Radhi, Zuhair Numan Hamed, Selda Sabah Ezzaldeen, Emad Abbas Jaffar Al-Mulla

Abstract

For the first time, one of the antibiotic nanoparticles such as a classical form of ampicillin trihydrate compound was studied. The electrochemical behavior of ampicillin nanoparticles was investigated in blood medium using cyclic voltammetric technique by glassy carbon electrode. The results showed that the oxidation-reduction current peaks of ampicillin nanoparticles in blood medium were different from that of micro particles. The nanoparticles acted as anti-oxidative antibiotic by making the oxidation current peak at 1 V disappear, while the oxidation peak of micro particles still appeared in blood medium; hence, ampicillin at micro form acted as oxidative reagent in blood medium. A good reliability and stability of glassy carbon electrode in blood medium was found with low values of RSD for oxidation-reduction current peaks at ± 0.52% and ± 0.038% respectively. Scanning electron microscopy for the characterization of ampicillin trihydrate nanoparticles was studied.

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Nano Biomedicine and Engineering.

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