Newly Developed Pharmacokinetics and Pharmacokinetics-Pharmacodynamics Modeling for Nano Drug Delivery System

Mingxi Ma, Shengxin Huang, Jiabi Zhu, Kunliang Liu, Fei Xiong

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Abstract

A clear and systematic understanding of drugs’ in vivo performance is of fundamental significance in drugs’ design, development, medical applications, and toxicity evaluation. Unlike traditional solution dosage forms that only consist of free drugs, nano-drug delivery systems (nano-DDS) are divided into two parts: free drugs and carried drugs. Carried drugs are the key to improving release and distribution in vivo. Studying the pharmacokinetics (PK) and pharmacodynamics (PD) of nano-DDS using the classical compartment models for traditional solution dosage forms will confuse the carried drugs with the free drugs, which would not be completely correct. In this paper, we proposed newly developed PK and PKPD models “linear multiple input and single output system” for nano-DDS, which can accurately predict the velocity and distribution of the two different parts. The study on the part of the carried drugs can provide the basis for the design of nano-DDS, and the harmonic design of the two parts can provide different schemes for varied clinical diseases with different requirements on the onset time and effect duration of drugs.

Nano Biomedicine and Engineering.

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