Investigation of Phloroglucinol Succinic Acid Dendrimer as Antimicrobial Agent against Staphylococcus Aureus, Escherichia Coli and Candida Albicans

In this study, antimicrobial investigations for the efficiently synthesized biocompatible PhloroglucinolSuccinic acid (PGSA) dendrimer with anionic surfaces were performed using broth dilution methodagainst a Gram-positive bacterium (Staphylococcus aureus), a Gram-negative bacterium (Escherichiacoli) and a fungal human pathogen (Candida albicans) to determine the minimal inhibitoryconcentration (MIC) value. Additionally, fluorescence and UV absorbance spectroscopy techniqueswere used to monitor the release of intracellular materials from the pathogens owing to anionicdendrimers. The exact binding sites of this dendrimer on these pathogens by molecular modellingstudies motivated us to report this nanocarrier as a new antimicrobial agent.