Hybrid Nanoparticles for Therapy and Diagnosis: Au Nano Prisms for Gastrointestinal Cancer
Jesús Martínez de la Fuente *
Instituto de Ciencia de Materiales de Aragón, CSIC-Universidad de Zaragoza, Spain (Aragon Institute of Materials Science, CSIC-University of Zaragoza, Spain); Department of Instrument Science and Engineering, Shanghai Jiao Tong University, P.R. China.
* Corresponding author. E-mail: email@example.com
Presented: 1st International Symposium of Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment Instrument (SHIIRC). Shanghai, China, Aug. 7, 2017; Published: Nov. 17, 2017
Citation: Jesús Martínez de la Fuente, Hybrid Nanoparticles for Therapy and Diagnosis: Au Nano Prisms for Gastrointestinal Cancer. Nano Biomed. Eng., 2017, Special Issue: 276.
In the last decades, inorganic nanoparticles have been steadily gaining more attention from scientists from a wide variety of fields such as material science, engineering, physics or chemistry. The very different properties compared to that of the respective bulk, and thus intriguing characteristics of materials in the nanometre scale, have driven nanoscience to be the centre of many basic and applied research topics. Moreover, a wide variety of recently developed methodologies for their surface functionalization provide these materials with very specific properties such as drug delivery and circulating cancer biomarkers detection. In this talk we describe the synthesis and functionalization of magnetic and gold nanoparticles as therapeutic and diagnosis tools against cancer.
Gold nanoprisms (NPRs) have been functionalized with PEG, glucose, cell penetrating peptides, antibodies and/or fluorescent dyes, aiming to enhance NPRs stability, cellular uptake and imaging capabilities, respectively. Cellular uptake and impact was assayed by a multiparametric investigation on the impact of surface modified NPRs on mice and human primary and transform cell lines. Under NIR illumination, these nanoprobes can cause apoptosis. Moreover, these nanoparticles have also been used for optoacoustic imaging, as well as for tumoral marker detection using a novel type of thermal ELISA nanobiosensor using a thermosensitive support.
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