Single Molecule Investigations on DNA Origami Platform

Mingdong Dong *


Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Denmark.


* Corresponding author. E-mail:


Presented: 1st International Symposium of Shanghai Engineering Research Center for Intelligent Diagnosis and Treatment Instrument (SHIIRC). Shanghai, China, Aug. 7, 2017; Published: Nov. 17, 2017


Citation: Mingdong Dong, Single Molecule Investigations on DNA Origami Platform. Nano Biomed. Eng., 2017, Special Issue: 280.



DNA nanotechnology provides a robust method for building nanoscale architectures. The programmable surfaces of 2D DNA origami provide an idea functional template to control the spatial orientation of individual molecules in accurate position. Such programmable DNA surfaces can be utilized for investigating biological molecules at single molecule level. DNA –based platform strategies was successfully applied to single molecule manipulation, activities of enzymes, surface polymerization and molecular recognition. This approach will benefit not only for DNA nanotechnology, but also for single molecule detection.


Copyright© Mingdong Dong. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Nano Biomedicine and Engineering.

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