Perilipin-1 Level as Risk Marker of Insulin Resistance in Morbidly Obese Patients

Hanaa Addai Ali, Ali Abbas Abo Algon, Shukryia Shadhan Chyad, Emad Abbas Jaffar Al-Mulla


Morbid obesity is a serious health condition that can interfere with basic physical functions such as breathing or walking. Those who are morbidly obese are at greater risk of illnesses including diabetes, high blood pressure, sleep apnea, gastro esophageal reflux disease, gallstones, osteoarthritis, heart disease, and cancer. This study was designed by taking 60 patients and 20 controls aged from 25 to 45 years with morbid obesity. A collection of samples was done by taking venous fasting blood samples from the patients and healthy volunteers after an overnight fasting. Insulin resistance was assessed using the homeostasis model assessment for insulin resistance, fasting blood glucose (FBG), glycated hemoglobin A1c (HbA1c) and lipid profile kits were used to determine these parameters. It was observed that the increase level of perilipin-1 led to insulin resistance and hyperinsulinemia for 60 patients, while the level of perilipin-1 in 20 controls caused insulin sensitivity. The increase of all studied parameters was concluded from the p-value, which was less than 0.05.  The results also indicated that the level of perilipin-1 could be considered a risk factor for many diseases. It could cause accumulation of the bad cholesterol in vascular tissues leading to atherosclerosis; it could cause changes in many factors in secretion, could cause insulin resistance and then diabetes mellitus. The level of fatty acid coming from continuous lipolysis causes fatty liver and live diseases. 

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Nano Biomedicine and Engineering.

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