Formulation and Evaluation of Cox-2 Inhibitor (Etoricoxib) Loaded Ethyl Cellulose Nanoparticles for Topical Drug Delivery
Abbaraju Krishna Sailaja *, Naheed Begum
Department of Pharmaceutics, RBVRR Women’s College of Pharmacy Affiliated to Osmania University, Barkatpura, Hyderabad, India.
* Corresponding author. E-mail: firstname.lastname@example.org
Received: Oct. 20, 2017; Accepted: Dec. 25, 2017; Published: Jan. 26, 2018
Citation: Abbaraju Krishna Sailaja, Naheed Begum, Formulation and Evaluation of Cox-2 Inhibitor (Etoricoxib) Loaded Ethyl Cellulose Nanoparticles for Topical Drug Delivery. Nano Biomed. Eng., 2018, 10(1): 1-9.
The aim of this investigation was to formulate, characterize and evaluate etoricoxib (ET) loaded polymeric nanoparticles for topical delivery. For nanoprecipitation method, ethyl cellulose (EC) was used as polymers. All the formulations were prepared by varying the drug and polymer concentrations. The obtained nanoparticles were evaluated for yield, drug content, entrapment efficiency, loading capacity and in-vitro drug release. Comparative study was performed among the formulations of ethyl cellulose. For the formulation of the gel, carbopol 934 was used as a gelling base. By comparison, F3 formulation of ethyl cellulose was found to be the best with the highest entrapment efficiency of 79.1%, the smallest mean particle diameter (538 nm), a higher stability (-43.8 mV) and the ability to control the release for 12 h with 87.1% drug release. F3 formulation was incorporated into gel F3G. Based on the results, it could be concluded that F3G formulation of etoricoxib topical gel prepared with ethyl cellulose was found to be more efficient with the highest spreadability of 41.22 g.cm/sec and was able to sustain the drug release for about 12 h with a cumulative release of 79.1%.
Keywords: Polymeric nanoparticles; Etoricoxib; Nanoprecipitation; Zeta potential; Gel
The present conventional drug delivery systems often has side effects and complications due to their wide distribution throughout the body fluids. The localization of drug action in the injured tissue is a promising way to solve this problem. The object of drug targeting is to achieve a desired pharmacological response at a selected site without undesirable interactions at other sites. At present, drug targeting is achieved with one of two approaches. The first approach involves chemical modification of the parent compound to a derivative which is activated only at the target site. The second approach utilizes carriers such as liposomes, microspheres, nanoparticles, antibiotics, cellular carriers (erythrocytes and lymphocytes) and macromolecules to direct the drug at its site of action . The field of nanotechnology is one of the most active research areas in modern materials science. Nanoparticles exhibit new or improved properties based on specific characteristics such as size, distribution and morphology. There have been impressive developments in the ﬁeld of nanotechnology in the recent past years, with numerous methodologies developed to synthesize nanoparticles of particular shape and size depending on specific requirements. New applications of nanoparticles and nanomaterials are increasing rapidly . Nanotechnology can be termed as the synthesis, characterization, exploration and application of nano-sized (1-1000 nm) materials for the development of science. It deals with the materials whose structures exhibit significantly novel and improved physical, chemical and biological properties, phenomena and functionality due to their nano-scaled size. Because of their size, nanoparticles have a larger surface area than macro-sized materials. Nanoparticles, because of their small