Single Molecular Theranostics for Cancer Targeted Therapy

Lintao Cai *

 

Guangdong Key Laboratory of Nanomedicine, CAS Key Lab for Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen 518055, PR China.

 

* Corresponding author. E-mail: lt.cai@siat.ac.cn

 

Presented: 2018 Chinese Conference on Oncology. Shenyang, China, Aug. 17-19, 2018; Published: Oct. 16, 2018

 

Citation: Lintao Cai, Single Molecular Theranostics for Cancer Targeted Therapy. Nano Biomed. Eng., 2018, Special Issue: 305.

 

Abstract

We report here a versatile small-molecule theranostic probe RhoSSCy using a stimuli-responsible linker and tunable functional group to realize dual-stimuli thiols/pH sensing. The results indicate that RhoSSCy is highly sensitive for quantitative analysis and imaging intracellular pH gradient and biothiols. Furthermore, RhoSSCy not only shows superb cancer targeted dual-modal imaging via near-infrared fluorescence (NIRF) and photoacoustic (PA), but also induce strongly reactive oxygen species for cancer photodynamic therapy (PDT) with robust antitumor activity in vivo. Such versatile small-molecule theranostic probe may be promising for cancer targeted imaging and precision therapy.

 

Keywords: Single molecular probe; Theranostics; Molecular imaging; Phototherapy; Cancer therapy

 

Copyright© Lintao Cai. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

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