Single Molecular Theranostics for Cancer Targeted Therapy

Lintao Cai *


Guangdong Key Laboratory of Nanomedicine, CAS Key Lab for Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences, Shenzhen 518055, PR China.


* Corresponding author. E-mail:


Presented: 2018 Chinese Conference on Oncology. Shenyang, China, Aug. 17-19, 2018; Published: Oct. 16, 2018


Citation: Lintao Cai, Single Molecular Theranostics for Cancer Targeted Therapy. Nano Biomed. Eng., 2018, Special Issue: 305.



We report here a versatile small-molecule theranostic probe RhoSSCy using a stimuli-responsible linker and tunable functional group to realize dual-stimuli thiols/pH sensing. The results indicate that RhoSSCy is highly sensitive for quantitative analysis and imaging intracellular pH gradient and biothiols. Furthermore, RhoSSCy not only shows superb cancer targeted dual-modal imaging via near-infrared fluorescence (NIRF) and photoacoustic (PA), but also induce strongly reactive oxygen species for cancer photodynamic therapy (PDT) with robust antitumor activity in vivo. Such versatile small-molecule theranostic probe may be promising for cancer targeted imaging and precision therapy.


Keywords: Single molecular probe; Theranostics; Molecular imaging; Phototherapy; Cancer therapy


Copyright© Lintao Cai. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Nano Biomedicine and Engineering.

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