Inorganic Theranostic Agents as the Tumor Microenvironment-Mediated Nanoplatform for Tumour-Specific Therapy

Wenbo Bu *

 

Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, P. R. China.

 

* Corresponding author. E-mail: wbbu@chem.ecnu.edu.cn

 

Presented: 2018 Chinese Conference on Oncology. Shenyang, China, Aug. 17-19, 2018; Published: Oct. 17, 2018

 

Citation: Wenbo Bu, Inorganic Theranostic Agents as the Tumor Microenvironment-Mediated Nanoplatform for Tumour-Specific Therapy. Nano Biomed. Eng., 2018, Special Issue: 308.

 

Abstract

In this talk, I will focus on the latest progresses of our group on a variety of inorganic theranostic agents as the tumor microenvironment-mediated nanoplatform for the tumour-specific therapy. First, I will offer a thorough description of chemodynamic therapy (CDT), which is defined as the disproportionation of hydrogen peroxide (H2O2) through an intratumoral Fenton reaction. Such an endogenous chemical energy to generate cytotoxic·OH could substantially surmount the limitations of penetration and nonspecificity. Then, I will introduce the specific cancer-starving therapy. We provides a compelling proof-of-concept for the use of PVP-modified Mg2Si nanoparticles as potential candidates for use as a tumor-targeted deoxygenating agent. This cancer-starvation therapy avoids the poisoning of normal/cancer cells by toxic drugs, and largely reduces the toxic side effects to normal cells and tissues, featuring high therapeutic biosafety.

 

Keywords: Microenvironment-mediated theranostic agents; Chemodynamic therapy; Cancer-starvation therapy

 

Copyright© Wenbo Bu. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

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