Structure-Efficacy Relationship Studies on Drug-Conjugated Gold Nanoparticles

Yingying Zhou 1, Juanjuan Liang 1, 2, Dongyan Wu 1, Teng Cui 1, 2, Can Zhang 2, Ya Ding 1*

 

1 State Key Laboratory of Natural Medicines, Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, P. R. China.

2 Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases, Center of Drug Discovery, China Pharmaceutical University, Nanjing 210009, P. R. China.

 

* Corresponding author. E-mail: dingya@cpu.edu.cn  

 

Presented: 2018 Chinese Conference on Oncology. Shenyang, China, Aug. 17-19, 2018; Published: Oct. 17, 2018

 

Citation: Yingying Zhou, Juanjuan Liang, Dongyan Wu, Teng Cui, Can Zhang, and Ya Ding, Structure-Efficacy Relationship Studies on Drug-Conjugated Gold Nanoparticles. Nano Biomed. Eng., 2018, Special Issue: 314.

 

Abstract

Drug-conjugated nanoparticle is a uniquely structured drug delivery system. In each conjugate, the nanoparticle acts as a core to crosslink more than 100 prodrug molecules and prodrug is composed of its parent drug molecules covalently connected on the surface of nanoparticles via proper spacers. This system can be seen the assembly of prodrugs in the nanoscale and show the advantages of both prodrug and nanoparticles. To investigate the structure-efficacy relationship of this system, gold nanoparticles (GNPs) and Doxorubicin (Dox) are selected as the demonstrations to construct Dox-conjugated GNPs. Polyethylene glycol (PEG) is used as the spacer to improve the solubility, biocompatibility, and body circulation of the system. Here, the position of Dox, size of gold core, and molecular weight of PEG are adjusted to regulate the in vitro properties and in vivo performance of Dox-conjugated GNPs systematically. According to the structure-efficacy relationship studies of Dox-conjugated GNPs, it allows to reveal the internal mechanism that guides therapy of tumor treatment, explore physicochemical and material science approaches to improve the therapy efficacy of nanoconjugates, and promote the theoretical and practical researches of nanoparticle-based drug delivery system as the candidate for tumor treatment.

 

Keywords: Structure-efficacy relationship; Gold nanoparticles; Drug conjugates; Nano-prodrug; Antitumor treatment

 

Copyright© Yingying Zhou, Juanjuan Liang, Dongyan Wu, Teng Cui, Can Zhang, and Ya Ding. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

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