Protein Biomimetic Diagnostic Probe

Weitao Yang, Bingbo Zhang *


Medical School of Tongji University, Shanghai, 200092, China.


* Corresponding author. E-mail:


Presented: 2018 Chinese Conference on Oncology. Shenyang, China, Aug. 17-19, 2018; Published: Oct. 18, 2018


Citation: Weitao Yang, Bingbo Zhang, Protein Biomimetic Diagnostic Probe. Nano Biomed. Eng., 2018, Special Issue: 321.



Molecular probes are an important part in the diagnosis and treatment of diseases. However, the non-specific adsorption of probes is seriously affecting the detection accuracy and sensitivity. We focus on addressing the above problems. By using protein-mediated biomimetic strategy, a series of scientific research, including surface engineering of nanoparticles with proteins, protein-mediated biomimetic synthesis and the related mechanism study have been carried out in a green chemistry fashion. It includes: (1) it is the first time that hydrophobic nanoparticles have been modified by BSA protein with its hydrophobic cavum exposed by the ultrasonic effect, greatly reducing nonspecific adsorption or "protein corona" of nanoprobes; (2) it discloses that some related amino acids have important roles in the biomimetic chemistry, and provides a green, simple and efficient route for integration of multi-functional moieties for cancer diagnosis and treatment.


Copyright© Weitao Yang, Bingbo Zhang. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Nano Biomedicine and Engineering.

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