Polyethylene Glycol-Functionalized Magnetic (Fe3O4) Nanoparticles: A Novel DNA-Mediated Antibacterial Agent

Majid Sakhi Jabir, Uday Muhsen Nayef, Waleed Kamel Abdul Kadhim

Abstract

The Fe3O4-PEG magnetic nanoparticles (NPs) were prepared by hydrothermal method at different concentrations (FeCl3·6H2O, 0.75mg/mL; and FeCl3·6H2O, 1.5 mg/mL) and subsequently surface-functionalized coating with polyethylene glycol (PEG), the successful coating of PEG molecules on the surface of Fe3O4. These magnetic NPs exhibited good dispersibility and dissolvability in physiological condition. The obtained magnetic nanoparticles were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, thermogravimetry (TG) and vibrating sample magnetometer (VSM). The antibacterial activity of Fe3O4-PEG magnetic nanoparticles was studied against two bacterial strains: Gram-positive Staphylococcus and Gram-negative Escherichia coli aureus. The modified magnetite NPs had a significant effect more on S. aureus and less on E. coli. The results showed polyethylene glycol-functionalized magnetic (Fe3O4) nanoparticles as a novel DNA-mediated antibacterial agent.

Nano Biomedicine and Engineering.

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