Rifampicin: Electrochemical Effect on Blood Component by Cyclic Voltammetry Using Nano-Sensor

Muhammed Mizher Radhi, Anfal Ismael Ibrahim, Yousif Kadhim Al-Haidarie, Sura Ali Al-Asadi, Emad Abbas Jaffar Al-Mulla

Abstract

Rifampicin (RIF) compound was analyzed by electrochemical study using cyclic voltammetric method to characterize the electrochemical properties in blood medium. Glassy carbon electrode (GCE) was modified with carbon nanotubes (CNT) as a high sensitive sensor for using in the electro-analysis of RIF in blood medium. It was found that oxidation and reduction current peaks of RIF in blood medium were at the potential of 0.5 and -0.5 V, respectively. Different concentrations, pH, scan rates, reliability and stability of RIF in blood medium were studied. The diffusion coefficient of oxidation and reduction was determined using the Randles-Seveik equation. The result showed the average value of oxidation and reduction were 2.66 × 10-5 and 8.72 × 10-5 cm2s-1, respectively.

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Nano Biomedicine and Engineering.

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