Designing a Novel Nano-Vaccine against SARS-CoV-2

Ang Gao, Hui Liang, Qi Shen, Cheng Zhou, Xiao Min Chen, Jing Tian, Xueling Li, Zexi Liu, Jian Ni, Daxiang Cui

Abstract

The new coronavirus SARS-CoV-2 has become a global pandemic, which has had a huge impact on the lives of people around the world and has caused huge impacts and losses on global economic development. To now, there is still no effective drug or therapy against coronavirus. A large number of studies have shown that vaccines are the ultimate weapon to eliminate major infectious diseases. The development of new vaccines against new coronaviruses is the best way to prevent new coronavirus infections. In this study, we developed a new vaccine against the new coronavirus by combining our self-developed nano adjuvant loaded with carnosine graphene oxide adjuvant with loaded with CpG molecule and RBD protein antigen. Our results showed that this vaccine can produce high titer anti-SARS-CoV-2 RBD antibody neutralizing SARS-CoV-2 in mice within 2 weeks.

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Nano Biomedicine and Engineering.

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