Exploring the Role of Phytochemicals: Effect of [6]-Gingerol Combined with Colloidal Gold Nanoparticles on Thyroid Carcinoma Cells

Majid S. Khalaf, Marwa Abdul Muhsien Hassan, Asmaa Hadi Mohammed



Gold nanostructure can be manufactured in many forms, such as spherical by using simple chemical method. X-ray powder diffraction (XRD) pattern of gold nanoparticles (AuNPs) was derived from a 400-μL trisodium citrate solution. The diffraction peaks corresponding to the diffraction planes of (111), (200), and (220) were all indexed to the gold with a face-centered cubic structure. The lattice constant calculated from the XRD pattern is 4.078 Å, which matches the conventional cubic gold metal diffraction pattern well (Pattern card number (04-784)). The results of scanning electronic microscope show that the biological nanoparticles of gold have asymmetric shapes and different sizes grouped as a circular particle. It was observed that the fashioning of AuNPs increased with increase in the concentration of [6]-gingerol waste extracts. The viability of FTC-133 cells treated for 48 h with various concentrations of [6]-gingerol extract coated with AuNPs (12.5–400 g/mL) was used to determine the cytotoxicity. A dose-dependent reduction in FTC-133 cell viability caused by [6]-gingerol extract capped with Au NPs was substantial (P < 0.05), reaching 75% cell mortality at 400 g/mL; the IC50 was 90.5%.

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Nano Biomedicine and Engineering.

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